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In addition to maintaining hepatic metabolic homeostasis, AMPK activation has been reported to promote mitochondrial function and suppress endoplasmic reticulum (ER) stress 22
It has been noted that younger children may be less susceptible to APAP-induced hepatotoxicity because of increased glutathione stores or metabolism differences as a result of genetic variability ( N -acetyl- p -benzoquinone imine (NAPQI) and increased hepatotoxicity ( Figure 1 for the pathway)
Signaling Pathway Map
identified and purified HGF in rat platelets (Nakamura et al., 1984
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